Anti-hINSR [IR 18-40]

Absolute Antibody

Anti-hINSR [IR 18-40]

9

This antibody reacts with the extracellular domain of human INSR, and recognises an epitope on the beta subunit. It does not cross-react with rat or mouse insulin receptors, and cross-reacts weakly with rabbit, bovine, porcine and ovine INSR.

This antibody has been used in immunoprecipitation assays, with both radiolabelled human insulin receptor (hINSR) and hINSR-radiolabelled insulin complexes (Soos et al, 1986). This antibody has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986), revealing that it reacts with the receptors beta subunit. This antibody has been shown to have limited inhibitory effect on insulin binding to IM-9 cells (Soos et al, 1986).

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

IR 18-40

INSR

insulin receptor

CD220; HHF5; insulin receptor; IR

Rabbit

IgG

Insulin receptor

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203