Anti-hINSR [IR 47-46]

Absolute Antibody

Anti-hINSR [IR 47-46]

9

This antibody reacts with human INSR, recognising an epitope on the alpha subunit (amino acids 485-592). It does not cross-react with rat or mouse insulin receptors, and does cross-react with bovine and rabbit receptors.

This antibody has been used in immunoprecipitation assays with radiolabelled human insulin receptor (hINSR) (Soos et al, 1986). It has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986), revealing that it binds to the receptors alpha subunit. This antibody has been shown to cause >80% inhibition of insulin binding to IM-9 cells (Soos et al, 1986), and to block receptor activation.

ImmunoPrecipitation, Western Blot, Neutralisation/Blocking

Research Use Only

Monoclonal

IR 47-46

INSR

insulin receptor

CD220; HHF5; insulin receptor; IR

Human

IgG1

Insulin receptor

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Bovine, Human

-20°C,2°C to 8°C

12352203