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Anti-Histone H2A.X Mouse mAb

PTM-1005
PTM BIO
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Histone H2A.X Mouse mAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Histone H2A.X Mouse mAb detects endogenous levels of histone H2A.X protein. It does not cross-react with other histone or non-histone proteins.
  • Applications
    Western Blot
  • Applications Supplier
    WB
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2H8
  • Conjugate
    Unconjugated
  • Host
    Mouse
  • Isotype
    IgG
  • Protein IDP16104
  • Protein Name
    Histone H2AX
  • Scientific Description
    Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Among core histones, the H2A family shows the highest sequence divergence, especially in the C-terminal region, leading to variants including H2A.Z, H2A.X, MacroH2A, H2A.B etc. H2A histone family member X (H2A.X) is a histone H2A variant encoded by the H2AFX gene. H2A.X contributes to nucleosome-formation, chromatin-remodeling and DNA double-strand break repair and is considered as a tumor suppressor. An early cellular response to DNA damage is the rapid Phosphorylatedrylation of H2A.X at position Ser139.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein G and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Meigui Zhang, et al. '(2E)-1-(2,4,6-Trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one, a Chalcone Derivative, Promotes Apoptosis by Suppressing RAS-ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells' CHEMISTRY & BIODIVERSITY (2023)
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