Anti-HIV-1 protease [F11.2.32]
AB00805-23.0-BT
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityVirus
Overview
- SupplierAbsolute Antibody
- Product NameAnti-HIV-1 protease [F11.2.32]
- Delivery Days Customer9
- Antibody SpecificityF11.2.32 Fab binds to HIV-1 PR with a dissociation constant of 5 nM (determined by SPR at pH5.2) at an epitope consisting of MSLPGRWKPKM (aa 36-46). HIV-1 PR is a homodimeric apartate protease that specifically cleaves the viral Gag and Gag/Pol polyprotei
- Application Supplier NoteThe IgG and Fab variants of F11.2.32 are both able to strongly inhibit the catalytic activity of HIV-1 PR (IC50 ~35 nM). Inhibition occurs by distorting the native structure of the HIV-1 PR at the base of the flap region, which plays an important role in regulating access to the active site. This antibody is also able to detect HIV-1 PR by ELISA.
- ApplicationsELISA, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDF11.2.32
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- ReactivityVirus
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203