Bio-Connect

Anti-HIV-1 protease [F11.2.32]

AB00805-23.0-BT
Absolute Antibody
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityVirus
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-HIV-1 protease [F11.2.32]
  • Delivery Days Customer
    9
  • Antibody Specificity
    F11.2.32 Fab binds to HIV-1 PR with a dissociation constant of 5 nM (determined by SPR at pH5.2) at an epitope consisting of MSLPGRWKPKM (aa 36-46). HIV-1 PR is a homodimeric apartate protease that specifically cleaves the viral Gag and Gag/Pol polyprotei
  • Application Supplier Note
    The IgG and Fab variants of F11.2.32 are both able to strongly inhibit the catalytic activity of HIV-1 PR (IC50 ~35 nM). Inhibition occurs by distorting the native structure of the HIV-1 PR at the base of the flap region, which plays an important role in regulating access to the active site. This antibody is also able to detect HIV-1 PR by ELISA.
  • Applications
    ELISA, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    F11.2.32
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
  • Reactivity
    Virus
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203