Anti-HIV GP41 [2E7 (L92E7)]

Absolute Antibody

Anti-HIV GP41 [2E7 (L92E7)]

9

This antibody binds a new linear epitope in the first heptad repeat of gp41 that is only exposed in the fusion-intermediate conformation.

This highly potent broadly neutralizing antibody binds HIV-gp41 and is capable of neutralizing HIV strains belonging to the A, A/G, B, B/C and C subtypes. The binding of the antibody to various envelope glycoprotein was confirmed using ELISA (PMID: 22438910). A bispecific VHH with 2E7 and CD4bs VHH (J3/3E3) was reported to enhance strain specific potencies up to 1400 folds higher than the mixture of the individual VHHs (PMID: 31544844).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

2E7 (L92E7)

env

Envelope surface glycoprotein gp160, precursor

Envelope surface glycoprotein gp160, precursor; HIV1gp8

Rabbit

IgG

Envelope glycoprotein gp160

This chimeric rabbit antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203