Anti-HIV p24 antibody; HIV gp120 antibody [1F7]

Absolute Antibody

Anti-HIV p24 antibody; HIV gp120 antibody [1F7]

9

The anti-idiotypic antibody recognizes antibodies that react to different components of the HIV virus, such as gp120, p24. The antibody does not react with antibodies derived from SLE and B cell lymphoma.

The HIV-1 antigen capture ELISA was used to test the binding of human monoclonal anti-HIV-1 to the antibody. The antibody bound to anti-p24 antibodies and anti-gp120 antibodies. Western blot analysis confirmed that the antibody reacts with human antibodies of different HIV-1 antigen specificities (Wang et al., 1992; PMID: 1378015). SHIV-infected macaques were immunized with the antibody. Significant increases in breadth and potency of HIV-1 neutralizing antibody titers to one or more virus strains were detected in all three of the 1F7 immunized macaques (US6057421A).

Western Blot, ELISA, Other Application

Research Use Only

Monoclonal

1F7

Rabbit

IgG

Human

-20°C,2°C to 8°C

12352203