Anti-HLA allele DQB10601 [LG11]

Absolute Antibody

Anti-HLA allele DQB10601 [LG11]

9

This antibody recognises peptides corresponding to the tip of the MHC antigen-binding cavity (region 70 - 90) of HLA allele DQB1*0601 (RTRAELDTVCRHNYEVAFRGI). It cross-reacts with peptide DQB1*03/70-90, and the shorter peptide DQB1*06/70-79

This antibody blocks the myasthenia gravis (MG)-associated DQ beta 1 allele, and is able to inhibit the proliferation of T cells from MG patients (Ayyar & Atassi, 2017). A humanised scFv derived from this antibody, which has been confirmed in ELISA analysis to recognise the same epitope, is also able to block the proliferation of T cells from MG patients typed DQB1*0601 (Ayyar & Atassi, 2017).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

LG11

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203