anti-HLA F antibody [3D11]

Arigo Biolaboratories

anti-HLA F antibody [3D11]

23

Flow Cytometry, Western Blot

Research Use Only

Monoclonal

3D11

1 mg/ml

Unconjugated

HLA-F

major histocompatibility complex, class I, F

CDA12; HLA class I histocompatibility antigen, alpha chain F; HLA F antigen; HLA-5.4; HLA-CDA12; HLAF; leukocyte antigen F; MHC class I antigen F

Mouse

IgG1

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203