anti-HP1 alpha antibody

Arigo Biolaboratories

anti-HP1 alpha antibody

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1 mg/ml

Unconjugated

CBX5

chromobox 5

antigen p25; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1; HP1 alpha homolog; HP1A; HP1-ALPHA; HP1Hs alpha

Mouse

IgG2b

Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins

Human

-20°C

12352203