Anti-Hu CD117 Alexa Fluor(r) 700

EXBIO

Anti-Hu CD117 Alexa Fluor(r) 700

7

The mouse monoclonal antibody 104D2 detects extracellular part of CD117 / c-Kit protooncogen.

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 microl reagent / 100 microl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Flow Cytometry

Research Use Only

104D2

AlexaFluor 700

IgG1

CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.

Bovine, Human, Primate

2°C to 8°C

12352203