Anti-Hu CD158d Purified Low Endotoxin

EXBIO

Anti-Hu CD158d Purified Low Endotoxin

7

The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.

Flow cytometry: Recommended dilution: 2-6 microg/ml. Functional application: Activation.

Functional Assay, Flow Cytometry, ImmunoPrecipitation, ImmunoCytoChemistry

Research Use Only

mAb#33

1 mg/ml

IgG1

CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.

Human

2°C to 8°C

12352203