Anti-Hu CD81 Purified Low Endotoxin

EXBIO

Anti-Hu CD81 Purified Low Endotoxin

7

The antibody M38 reacts with an extracellular epitope of CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.

Functional application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines. Flow cytometry: recommended dilution: 1 microg/ml. Western blotting: recommended dilution: 1-2 microg/ml; positive control: Jurkat cells, non-reducing conditions.

Functional Assay, Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

M38

1 mg/ml

IgG1

CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells, e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.

Feline, Human, Rabbit

2°C to 8°C

12352203