Anti-Human CD3-FITC/CD4-PE/CD8a-PE/Cyanine7/CD45-PerCP Cocktail

Reddot Biotech

Anti-Human CD3-FITC/CD4-PE/CD8a-PE/Cyanine7/CD45-PerCP Cocktail

5

Flow Cytometry

Research Use Only

OKT-3,RPA-T4,OKT-8,HI30

Double Conjugated, FITC, PerCP, RPE

This product is a FCM antibody cocktail made up of FITC Anti-Human CD3 Antibody [Clone: OKT-3] (Mouse IgG2a, kappa),PE Anti-Human CD4 Antibody [Clone: RPA-T4] (Mouse IgG1, kappa), PE/Cyanine7 Anti-Human CD8a Antibody[Clone: OKT-8] (Mouse IgG2a, kappa) and PerCP Anti-Human CD45 Antibody [Clone: HI30] (Mouse IgG1, kappa). CD3 is a heterotetrameric protein consisting of a CD3Oe≥, a CDOe and 2 CD3Oemicro. It forms complex with TCR. OKT-3 recognize human CD3Oemicro. Human CD3 is expressed on the surface of T cells and NKT cells. CD4 is also called Leu-3 or T4. Its a single-chain type I transmembrane glycoprotein, mainly expressed on the surface of T cells, and monocytes/macrophages. In T cells, CD4 forms complex with TCR/CD3 and play important roles in T cell immunity. The target of HIV is CD4+ T cells. Reduction of CD4+ T cells is the main reason of defected immunity after HIV infection. CD8 is mainly expressed on cytotoxic T cells and also some subpopulations of NK cells. CD8 forms dimer function. In most cells, CD8 is a heterodimer consisting of CD8a and CD8b, but in NK cells nearly all CD8 is homodimer of CD8a. CD8a can form co-receptor with MHC-I restricted TCR to promote T cell antigen recognition and activation. CD45 is a single-chain type I transmembrane glycoprotein. Except for erythrocytes and platelets, CD45 is expressed on nearly all of the hematopoietic cells with high level. It is a common marker for blood leukocytes. CD45 is a receptor type protein tyrosine phophatase and plays essential roles in B cell and T cells signaling.

Human

2°C to 8°C

12352203