Anti-iC3b [6G1]

Absolute Antibody

Anti-iC3b [6G1]

7

This antibody recognizes a conformational epitope on the human iC3b.

This antibody binds iC3b with a dissociation constant of 43.3 nM. This antibody can be used in combination with 5D2 to detect iC3b in a sanwich ELISA. This antibody was used to identify iC3b using immunoprecipitation. This antbody was also used for the immunohistochemical analysis of Alzheimers disease brain and was successful in labelling plaques with various morphologies in the grey matter at a 0.625 microg/mL dilution. This antibody can successfully stain human bruchs membrane/choroid tissues samples from patients having age related macular degeneration (AMD). It was able to identify drusen associated with bruchs membrane in stage 3 and 4 AMD tissues (US20140127225).

ImmunoPrecipitation, ELISA, ImmunoHistoChemistry

ELISA; IP; IHC

Research Use Only

Monoclonal

6G1

C3

complement C3

acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a; C3a anaphylatoxin; C3b; complement C3; complement component 3; complement component C3a; complement component C3b; CPAMD1; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; prepro-C3

Human

IgG1

Complement C3

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

The original antibody was generated by immunizing mice intraperitoneally with human iC3b protein mixed with RIBI adjuvant.

-20°C,2°C to 8°C

12352203