Anti-ICOS [3F12]

Absolute Antibody

Anti-ICOS [3F12]

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This antibody specifically recognizes canine ICOS, which enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibo

3F12 can be used to identify canine ICOS and analyse its activity. The antibody is an antagonist of ICOS and exhibits the ability to significantly suppress mixed leukocyte reactions (MLR) (Sato et al., 2013; pmid: 23694952). Anti-ICOS antibody was also shown to be an effective agent that can be used in the treatment development of Canine Chronic Graft-versus-Host Disease (GVHD) (Graves et al., 2017; pmid: 28958896).

Flow Cytometry, ELISA, Neutralisation/Blocking

FC; blocking; ELISA

Research Use Only

Monoclonal

3F12

Canine

IgG4

Inducible T-cell costimulator

This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Canine

Dog

This antibody was raised by immunizing RBF/DnJ mice with caICOS-murine-IgG2a fusion and hybridomas were generated using accepted methods.

-20°C,2°C to 8°C

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