Anti-ICOS ligand [Clone 325]

Absolute Antibody

Anti-ICOS ligand [Clone 325]

9

This antibody binds human B7RP-1, which is a ligand for T-cell-specific cell surface receptor ICOS. It acts as a costimulatory signal for T-cell proliferation and cytokine secretion and also induces B-cell proliferation and differentiation into plasma cel

The scFv version of this antibody binds B7RP-1-Fc with a Kd= 22nM. The binding specificity of this antibody was confirmed using ELISA. This scFv version of this antibody was shown to bind B7RP-1-Fc in an ELISA. This antibody recognized B7RP-1 molecules expressed on B cells, as assessed by flow cytometry. This antibody is capable of inhibiting interaction between ICOS-Fc and B7RP-1-Fc. This antibody also exhibited inhibitory activity in a proliferation assay of T cells stimulated with anti-CD3 mAb and B7RP-1-Fc (Maeda et al., 2009; PMID: 20065650).

Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Clone 325

ICOSLG

inducible T cell costimulator ligand

B7 homolog 2; B7 homologue 2; B7h; B7H2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP1; B7RP-1; CD275; GL50; ICOS ligand; ICOSL; ICOS-L; LICOS; transmembrane protein B7-H2 ICOS ligand

Rabbit

IgG

ICOS ligand

Human

-20°C,2°C to 8°C

12352203