Anti-IL-13 [CNTO607]

Absolute Antibody

Anti-IL-13 [CNTO607]

9

This antibody binds an epitope at the surface formed by helices A and D of human interleukin-13. This epitope overlaps with the IL-4Ralpha/IL-13Ralpha1 receptor-binding site, which explains the neutralizing effect of CNTO607. IL-13 is a cytokine secreted

The original IgG1 version of this antibody binds human IL-13 with an affinity of 18pM and prevents binding of IL-13 to both IL-13Ralpha1 and IL-4Ralpha. This antibody can bind native wild type and recombinant human IL-13 in an ELISA (PMID: 19361524). This antibody is capable of neutralizing IL13 activity in the TF-1 and in the IL-13Ralpha1 receptor binding assay (US20080044420). This antibody has the tendency to self associate. The IgG1 version of this antibody can be concentrated to ~13 mg/ml before irreversible precipitation occurs (PMID: 22915597). The relative binding affinity of the IgG1 version of this antibody was determined to be 18.4 pM (PMID: 22915597).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

CNTO607

IL13

interleukin 13

IL-13; interleukin-13; P600

Mouse

IgG2b

Interleukin-13

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203