Anti-IL-1A [6H3.1A4]

Absolute Antibody

Anti-IL-1A [6H3.1A4]

9

This antibody binds human Interleukin-1 alpha, which is a cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1al

The original mouse IgG antibody binds human IL-1A with a binding affinity of Kd= 0.35 nM. The binding characterization of this antibody was done using ELISA. In vitro antibody potency was determined by its ability to inhibit IL-8 production by MRC-5 cells. This antibody was able to inhibit IL-8 production by MRC-5 cells with an IC50 of 2.40E-10M. This antibody was used in combination with 6B12.4F6 (anti-IL-1beta) antibody for the generation of anti-human IL-1alpha/beta DVD-Ig molecule that had therapeutic potential (PMID: 20068402).

Functional Assay, ELISA

Research Use Only

Monoclonal

6H3.1A4

IL1A

interleukin 1 alpha

hematopoietin-1; IL1; IL-1 alpha; IL-1A; IL1-ALPHA; IL1F1; interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha

Mouse

IgG1

Interleukin-1 alpha

Human

-20°C,2°C to 8°C

12352203