Anti-IL-1B [MAb201]

Absolute Antibody

Anti-IL-1B [MAb201]

9

This antibody binds human Interleukin-1 beta, which is a potent pro-inflammatory cytokine. This antibody is reported to show some cross reactivity with recombinant mouse IL-1b. Initially discovered as the major endogenous pyrogen, induces prostaglandin sy

This antibody can be used in the detection of human IL-1b using western blot (PMID: 19465481). This antibody was used for the immunocytochemical staining of nuclear IL-1b in human breast cancer samples (PMID: 21057224). This antibody has been reported to neutralize the human IL-1 beta induced stimulation of proliferation in the D10.G4.1 mouse helper T cell line in a dose-dependent manner. This antibody inhibits binding of IL-1RAcP to IL-1 bound IL-1R1. This antibody is also reported to be as potent as IL-1ra in inhibiting IL-1 induced IL-6 in human chondrocytes. (US20030026806). Humanized version of this antibody is available on request.

Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

MAb201

IL1B

interleukin 1 beta

catabolin; IL-1; IL-1 beta; IL1beta; IL1-BETA; IL1F2; interleukin 1beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta

Rabbit

IgG

Interleukin-1 beta

Human

-20°C,2°C to 8°C

12352203