Anti-IL-2 [Jes6-1]

Absolute Antibody

Anti-IL-2 [Jes6-1]

9

This antibody binds murine IL-2.

JES6-1 is a scFv reformat of the variable domain sequences of the JES6-1 monoclonal antibody (Spangler et al, 2015). It was shown in this study that JES6-1 scFv binding to mouse IL-2 would sterically hinder interaction with the IL-2 receptor, thereby blocking downstream signalling functions. This antibody is well known as a neutralising antibody against mouse IL-2, and is useful for cytokine assays such as ELISA (Abrams et al, 1992).

ImmunoPrecipitation, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Jes6-1

Il2

interleukin 2

IL; Il-2; interleukin-2; T-cell growth factor; TCGF

Rabbit

IgG

Interleukin-2

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203