Anti-IL-20 [20A10]

Absolute Antibody

Anti-IL-20 [20A10]

9

This antibody binds a conformational epitope which can also be formed or mimicked by the human IL-20 derived peptide comprising amino acids 101-PDHYTLRKISSLANSFLT-118. It also cross reacts with mouse IL-20. IL-20 is a pro-inflammatory and angiogenic cytok

This antibody can bind a fusion protein of human IL-20 with Gaussia luciferase in a GLuc-sandwich ELISA. This antibody was capable of neutralizing recombinant IL-20 and IL-20 receptor mediated STAT3 activation and rhIL-20 and IL-20 receptor mediated induction of KZ136-NLuc Reporter Gene. The in vivo therapeutic effect of this antibody was studies using an ear inflammation assay in 8 weeks old C57BL/6J mice by intradermal injection of human cytokine IL-20. This antibody was successful in neutralizing the injected human IL-20 in a mouse model (US20170189524). The IgG4 version of this antibody binds human IL-20 with a very high binding affinity of Kd= 91fM (PMID: 27426947).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

20A10

IL20

interleukin 20

cytokine Zcyto10; four alpha helix cytokine; IL10D; IL-20; interleukin-20; ZCYTO10

Rabbit

IgG

Interleukin-20

Human, Mouse

-20°C,2°C to 8°C

12352203