Anti-IL-34 [FAb1.1]

Absolute Antibody

Anti-IL-34 [FAb1.1]

9

The antibody is specific for human and murine IL-34. The antibody recognizes a largely continuous area at the junction of two IL-34 protomers. The epitope overlaps largely with binding epitopes responsible for CSF-1R binding.

The crystal structure of the Fab fragment of the antibody in complex with human IL-34 was determined. The original antibody was reformatted as an IgG molecules and the binding affinity of both formats measured by BLI experiments (Kd= 17 nM and 120 pM respectively). The antibody blocked the biological activity of IL-34 in human monocyte viability. The antibody neutralized IL-34 in a proliferation assays (Ma et al., 2012; PMID: 22483114).

Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

FAb1.1

IL34

interleukin 34

C16orf77; IL-34; interleukin-34

Mouse

IgG2a

Interleukin-34

This is a reformatted mouse IgG2a Fc Silent™ antibody, based on the original mouse Fab format, created for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203