Anti-IL-6R [AUK12-20]

Absolute Antibody

Anti-IL-6R [AUK12-20]

7

This antibody binds the human IL-6 receptor at a site that is different from the epitope recognized by Tocilizumab (PM-1). The presence of this antibody inhibits the binding of IL-6 to the human IL-6R.

This antibody can be used to inhibit the binding of IL-6 to its receptor IL-6R. It is also reported to inhibit IL-6 functions. The binding characterization of this antibody was done using ELISA (US5795965). This antibody was also reported to inhibit IL-6 dependent tumor cell growth (PMID: 8152440). This antibody was used in a study wherein the combined effect of antigrowth factor receptor antibodies was tested on growth limitation of myeloma cells (PMID: 8120920).

ELISA, Neutralisation/Blocking

Inhibit; ELISA

Research Use Only

Monoclonal

AUK12-20

IL6R

interleukin 6 receptor

CD126; CD126 antigen; gp80; HIES5; IL-1Ra; IL-6 receptor subunit alpha; IL6Q; IL6QTL; IL-6R; IL-6R-1; IL6RA; IL-6RA; IL6RQ; interleukin-6 receptor subunit alpha; membrane glycoprotein 80

Rabbit

IgG

Interleukin-6 receptor subunit alpha

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

Human

The original antibody was generated by immunizing female BALB/c mice with 10 .mu.g/mouse of the soluble IL-6R (SR 344) immunogen in Freund's complete adjuvant.

-20°C,2°C to 8°C

12352203