Anti-IL-6R [D7715A7]

Absolute Antibody

Anti-IL-6R [D7715A7]

9

This antibody is specific for murine IL-6R.

This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990; Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60% and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001).

Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

D7715A7

Il6ra

interleukin 6 receptor, alpha

CD126; I; IL; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; Il6r; IL-6R; IL-6R 1; IL-6R subunit alpha; IL-6RA; IL-6R-alpha; interleukin-6 receptor subunit alpha

Mouse

IgG2a

Interleukin-6 receptor subunit alpha

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203