anti-IL12B / IL12 p40 antibody [CC301] (low endotoxin)

Arigo Biolaboratories

anti-IL12B / IL12 p40 antibody [CC301] (low endotoxin)

23

Functional Assay, Flow Cytometry, Western Blot, ELISA, ELISpot Assay

Research Use Only

Monoclonal

CC301

1 mg/ml

Unconjugated

IL12B

interleukin 12B

CLMF p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B; IL12p40; interleukin 12 40kDa subunit; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 subunit beta

Mouse

IgG2a

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Bovine

-20°C

12352203