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anti-IL15 antibody [B-E29] (low endotoxin)

ARG23355
Arigo Biolaboratories
ApplicationsFunctional Assay, Flow Cytometry, ELISA
Product group Antibodies
ReactivityHuman
TargetIL15
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-IL15 antibody [B-E29] (low endotoxin)
  • Delivery Days Customer
    23
  • Applications
    Functional Assay, Flow Cytometry, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    B-E29
  • Conjugate
    Unconjugated
  • Gene ID3600
  • Target name
    IL15
  • Target description
    interleukin 15
  • Target synonyms
    IL-15; interleukin-15
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each others activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203