Anti-inflammatory agent 54

Biorbyt

Anti-inflammatory agent 54

10

Research Use Only

98.00%

C17H16N2O5

328.32

Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-kappaB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-alpha, IL-6, and IL-1beta. It effectively suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 2.4 microM and demonstrates in vivo efficacy in a mouse auricular edema model [1].

C(CNC(/C=C/C1=CC=CO1)=O)N2C=3C(OC2=O)=CC(OC)=CC3

-20°C

12352200