Anti-influenza [2-8C]

Absolute Antibody

Anti-influenza [2-8C]

9

This antibody reacts with influenza A virus nucleoprotein (NP), which is a structural protein which encapsidates the negative strand viral RNA. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to intera

This antibody was used in virus titration and microneutralization assays to aid the development of pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity (Powell et al., 2012) and to demonstrate that a single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins (Powell et al., 2017). This antibody might be useful for Western blotting, immunofluorescence (IF) and immunocytochemistry (IHC), for instance, to better understand the differential replication properties among H9N2 avian influenza viruses of Eurasian origin (Parvin et al., 2015) and to validate that a conserved influenza A virus nucleoprotein code controls specific viral genome packaging (Moreira et al., 2016).

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

2-8C

IgG1

Nucleoprotein

This chimeric ferret antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203