Anti-influenza [T1-3B]

Absolute Antibody

Anti-influenza [T1-3B]

9

This antibody reacts with the stem (VH 1-69*01) of H5 hemagglutinin glycoprotein (HA). Haemagglutinin is an antigenic glycoprotein which allows viral attachment and entry into the cell. Sixteen subtypes of haemagglutinin (H1-H16) have been described, of w

In the original study, this antibody was used in conjunction with other mAbs (e.g. N2B10 mAb specific for the head of seasonal H3 HA; T2-9A mAb specific for the head of H1N1pdm09) for enzyme-linked immunosorbent, indirect immunofluorescent, virus titration, hemagglutination inhibition (HAI), and microneutralization (MN) assays to show that assessing antigenic relatedness of evolving influenza viruses with panels of defined, renewable, and human monoclonal antibodies could be a very useful an adjunct to ferret antisera in detection of antigenic drift and in the selection of viruses for inclusion in influenza vaccines (Huang et al., 2015).

ImmunoFluorescence, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

T1-3B

Human

IgM

Hemagglutinin

This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203