Anti-Insulin [mAb13]

Absolute Antibody

Anti-Insulin [mAb13]

7

This antibody binds human insulin. Insulin is a peptide hormone produced by the beta cells of the pancreatic islets. It reduces blood glucose concentration by promoting its absorption from the blood into liver, fat and skeletal muscle cells. Decreased or

This antibody is an affinity matured version of mab13 created by a point mutation in the variable heavy region S58R. The affinity of the IgG1 version of this antibody for insulin was found to be kd=59nM (PMID: 7995943). The binding specificity of the original IgG1 antibody for human insulin was determined using ELISA (PMID: 2159034).

ELISA

ELISA

Research Use Only

Monoclonal

mAb13

INS

insulin

IDDM; IDDM1; IDDM2; ILPR; insulin; IRDN; MODY10; PNDM4; preproinsulin; proinsulin

Rabbit

IgG

Insulin

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

Human

The original antibody was generated from the peripheral B cells obtained from an insulin-dependent (type I) diabetes mellitus (IDDM) patient treated with human recombinant insulin, by EBV transformation and somatic cell hybridization techniques.

-20°C,2°C to 8°C

12352203