anti-Insulin + Proinsulin antibody [D6C4]

Arigo Biolaboratories

anti-Insulin + Proinsulin antibody [D6C4]

23

ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

D6C4

Unconjugated

Ins2

insulin II

AA986540; In; Ins-2; InsII; insulin-2; Mod; Mody; Mody4; proinsulin

Mouse

IgG1

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Mouse

-20°C

12352203