anti-Insulin + Proinsulin antibody [D6C4]
ARG10643
ApplicationsELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityMouse
TargetIns2
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Insulin + Proinsulin antibody [D6C4]
- Delivery Days Customer23
- ApplicationsELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDD6C4
- ConjugateUnconjugated
- Gene ID16334
- Target nameIns2
- Target descriptioninsulin II
- Target synonymsAA986540; In; Ins-2; InsII; insulin-2; Mod; Mody; Mody4; proinsulin
- HostMouse
- IsotypeIgG1
- Scientific DescriptionAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
- ReactivityMouse
- Storage Instruction-20°C
- UNSPSC12352203