Anti-integrin alpha-5 beta-1 [339.1], Rabbit IgG, kappa

Absolute Antibody

Anti-integrin alpha-5 beta-1 [339.1], Rabbit IgG, kappa

9

This antibody is specific for alpha-5 beta-1

The original antibody was used for an ELISA on alpha-5 beta-1-Fc fusion protein. The original antibody was used for surface plasmon resonance on alpha-5 beta-1-Fc. It showed a binding affinity of 0.59 nM. This antibody was used for an Annexin V cell death assay. Furthermore this antibody was used for immunohistochemistry on Xenograft tumours derived from cells inoculated subcutaneously in ICR-SCID or SCID-Beige mice (Bhaskar et al., 2007; PMID:18042290). This antibody was used to test the effect of alpha-5 and beta-1 integrin blockers on OvCa cell lines HeyA8 and SKOV3ip1. Further this antibody was used for in vivo testing of alpha-5 and beta-1 integrin blocking antibodies using the HeyA8 xenograft model of OvCa metastasis. It showed a decrease in the number of tumours in the subjects (Kenny et al., 2014; PMID:25202979).

ELISA, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

339.1

Itga5

integrin alpha 5 (fibronectin receptor alpha)

CD49 antigen-like family member E; Cd49e; F; fibronectin receptor alpha polypeptide; fibronectin receptor subunit alpha; Fnra; integrin alpha-5; integrin alpha-F; VLA5

Rabbit

IgG

Integrin beta-1

Mouse

-20°C,2°C to 8°C

12352203