Anti-Integrin alpha-M [107]

Absolute Antibody

Anti-Integrin alpha-M [107]

9

This antibody binds to the MIDAS face of the A domain from integrin CD11b.

The antibody binds specifically to integrin alpha-M, a protein subunit of the alpha-M- beta-2 molecule, which is expressed on the surface of leukocytes. Integrin alpha-M is involved in the adhesive interaction between molecules of the innate immune system, and plays a role in the uptake of complement-coated particles. The monoclonal antibody 107 has a blocking activity by binding to the metal-ion-dependent-adhesion site, favouring a low affinity conformation of the antigen.

Flow Cytometry, ELISA

Research Use Only

Monoclonal

107

ITGAM

integrin subunit alpha M

antigen CD11b (p170); CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; MO1A; neutrophil adherence receptor alpha-M subunit; SLEB6

Human

IgG1

Integrin alpha-M

This chimeric human antibody was made using the variable domain sequences of the original IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203