Anti-Keratin (4,5,6,8,10,13,18) [C11]

Absolute Antibody

Anti-Keratin (4,5,6,8,10,13,18) [C11]

9

This antibody recognizes the human keratin, types 4, 5, 6, 8, 10, 13, and 18. Because of its wide range in keratin specificity, it often is referred to in literature as pan-keratin.

This original IgG1 antibody can be used to detect human keratin. Its specificity has been confirmed using immunofluorescence (Fehm et al., 2002; PMID: 12114406). One group used immunofluorescence to test if circulating epithelial cells were malignant (Fehm et al., 2002; PMID: 12114406), which was later built upon with the discovery that these cells remained in circulation until many years after treatment (Meng et al., 2004; PMID: 15623589). Another group used the antibodies with immunofluorescence and immunohistochemistry to visualize the progression of breast cancer once it had breached the epithelial cell layer (Khalil et al., 2017; PMID: 28894989). A final group used this antibody with immunofluorescence and western blotting to research the apoptotic response of keracinocytes to ultraviolet-B light (Mei, Lian, 2011; PMID: 21362287).

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

C11

KRT5

keratin 5

58 kda cytokeratin; CK5; CK-5; cytokeratin-5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin, type II cytoskeletal 5; KRT5A; type-II keratin Kb5

Human

IgG1

Keratin, type II cytoskeletal 5

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203