Anti-Ku80 Rabbit mAb

PTM BIO

Anti-Ku80 Rabbit mAb

5

ImmunoHistoChemistry Paraffin

IHC-P

Antibody

Research Use Only

Monoclonal

JRMR-205-1

Unconjugated

Rabbit

IgG

X-ray repair cross-complementing protein 5

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 Phosphorylatedrylation and subsequent innate immune response activation through the cGAS-STING pathway.Nucleus

Stable for 12 months from date of receipt/reconstitution.

Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203