Anti-L-Lactyl-Histone H4 (Lys12) Rabbit mAb

PTM BIO

Anti-L-Lactyl-Histone H4 (Lys12) Rabbit mAb

5

Anti-L-Lactyl-Histone H4 (Lys12) Rabbit mAb detects histone H4 when it is L-lactylated at Lys12.

ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry Paraffin

WB, IHC-P, IP, ChIP

Antibody

Research Use Only

Monoclonal

37H4L1

Unconjugated

Rabbit

IgG

Histone H4

Histones, fundamental proteins involved in chromatin structure and gene regulation, are subject to a wide array of enzyme-catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitination, and numerous others. Histone L-lactylation, a recently discovered post-translational modification induced by lactate has emerged as a significant addition to this repertoire. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The introduction of lysine L-lactylation is mediated by the acetyltransferase p300, while the removal of lactylation marks from histones has been attributed to Class I histone deacetylases (HDAC 1-3). Histone lactylation has been implicated in various biological processes, including inflammation, fibrosis, differentiation, and cancer progression.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203