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Anti-L-Lactyl-Histone H4 (Lys8) Rabbit pAb

PTM-1415
PTM BIO
ApplicationsWestern Blot, ChIP Chromatin ImmunoPrecipitation
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-L-Lactyl-Histone H4 (Lys8) Rabbit pAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-L-Lactyl-Histone H4 (Lys8) Rabbit mAb detects endogenous levels of histone H3 only when it is lactylated at Lys8.
  • Applications
    Western Blot, ChIP Chromatin ImmunoPrecipitation
  • Applications Supplier
    WB, ChIP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP62805
  • Protein Name
    Histone H4
  • Scientific Description
    Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation,ubiquitylation, etc. The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells. This phenomenon is intimately linked to several diseases including neoplasia, sepsis and autoimmune diseases.Lactate, which is converted from pyruvate in tumour cells, is widely known as an energy source and metabolic by-product. Zhang et al. (Nature, 2019) reveal that histone lactylation is a previously unknown histone modification,derived from the cellular metabolite lactate.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein A and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Qing Tian, et al. 'Lactate Activates Germline and Cleavage Embryo Genes in Mouse Embryonic Stem Cells' Cells (2022)
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  • Wang Jianwei, et al. 'Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration' Frontiers in Cellular and Infection Microbiology (2022)
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  • Xiaoxi Meng, et al. 'Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains' JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)
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  • Runhua Du, et al. 'Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis' iScience (2024)
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  • Wei Lin, et al. 'H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFkappaB signaling pathway' Journal of Neuroinflammation (2023)
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  • Hyunsoo Rho, et al. 'Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis' Cell Metabolism (2023)
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