Anti-L-Lactyllysine Antibody Conjugated Agarose Beads

PTM BIO

Anti-L-Lactyllysine Antibody Conjugated Agarose Beads

5

With the immobilization of highly specific Anti-L-Lactyllysine Antibodies, the Anti-L-Lactyllysine Antibody Conjugated Agarose Beads selectively capture peptides/proteins bearing L-lactyllysine residues, but do not cross-react with the peptides/proteins bearing other structurally similar modified residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine lactylation.

IAP

Antibody

Research Use Only

Mix

Agarose

Rabbit

IgG

Lactate, previously recognized solely as an energy source and metabolic byproduct, has now emerged as a crucial player in cancer biology, especially within the scope of the Warburg effect and its intricate interplay with various cellular processes, including angiogenesis, hypoxia, polarization of macrophages, and T cell activation. Recent investigations have unveiled an unprecedented function of lactate in the realm of histone modification, specifically through lysine L-lactylation, which exerts regulatory control over gene expression. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The acetyltransferase p300 is responsible for introducing lysine L-lactylation, while Class I histone deacetylases (HDAC 1-3) have been identified as an eraser of the lactylation marks on histones.

Stable for 12 months from date of receipt.

All Species

All

Store at -20°C. Avoid freeze/thaw cycles.

12352203