Anti-LAG-3 [Ab8438]

Absolute Antibody

Anti-LAG-3 [Ab8438]

7

The antibody is specific for human LAG-3. The antibody cross-reacts with cynomolgus LAG-3. The antibody does not cross react with murine LAG-3.

The antibody is a humanized version of the mouse antibody mab84c. The humanized antibody could bind to hLAG-3+ cells, with an EC50 value that does not exceed 1.5nM. The humanized antibody prevented the binding activity of human LAG-3 and Daudi cells. The binding affinity of the humanized antibody was measured by surface plasmon resonance (Kd= 0.71 nM). The antibody was employed to design bispecific antibodies against LAG-3 and PD-L1, which antibody retained the binding activity to dual-target LAG3 and PD-1. Further, both the combination of the antibody and PD-1 antibody and the bispecific LAG-3 and PD-L1 antibody showed a good tumour inhibition effect in in vivo application (CN111848794).

Other Application

SPR; in vivo

Research Use Only

Monoclonal

Ab8438

Rabbit

IgG

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG4 format for improved compatibility with existing reagents assays and techniques.

Human

Human

-20°C,2°C to 8°C

12352203