anti-LARGE1 antibody [LARGE-02]

Arigo Biolaboratories

anti-LARGE1 antibody [LARGE-02]

23

Flow Cytometry, Western Blot

Research Use Only

Monoclonal

LARGE-02

1 mg/ml

Unconjugated

LARGE1

LARGE xylosyl- and glucuronyltransferase 1

acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; glycosyltransferase-like protein LARGE1; LARGE; LARGE xylosyl- and glucuronyltransferase 1; MDC1D; MDDGA6; MDDGB6

Mouse

IgG2b

This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]

Human

-20°C

12352203