anti-LAT antibody [LAT-01]

Arigo Biolaboratories

anti-LAT antibody [LAT-01]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

LAT-01

1 mg/ml

Unconjugated

>95%

LAT

linker for activation of T cells

36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; IMD52; LAT1; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells family member 1; p36-38; pp36

Mouse

IgG1

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Human

-20°C

12352203