Anti-LIMK1 (Phospho-Thr508)

Applied Biological Materials

Anti-LIMK1 (Phospho-Thr508)

9

LIMK1 (phospho-Thr508) antibody detects endogenous levels of LIMK1 only when phosphorylated at threonine 508.

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 ug/ul

Rabbit

Phosphorylated

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

Human, Mouse, Rat

-20°C,2°C to 8°C

12352203