Anti-LMP1 [H3]

Absolute Antibody

Anti-LMP1 [H3]

7

H3 scFv is specific to the LMP1 C terminal region where it binds to CTAR-1 (GST-LMP1[187-242]). LMP1 is expessed constitutively in many EBV-associated tumours and this protein can cause B lymphocyte and rodent fibroblast transformation, cell apoptosis inh

H3 scFv can reduce LMP1-mediated NF-kappaB activation in HEK293 cells by ~50% as well as inhibit LMP1 functions in epithelial cells - enables the potential use of H3 for attenuating the LMP1 function in LMP1-positive tumors. H3 is also capable of reducing the trans-membrane migration ability of MDCK-LMP1 cells by blocking the CTAR-mediated signaling pathway. H3 can also be used to pull down LMP1 in IPs, and can be used for ELISAs and to visualise LMP1 distibution in IF studies.

ImmunoFluorescence, ImmunoPrecipitation, ELISA, Neutralisation/Blocking

ELISA; IP; IF; inhibit

Research Use Only

Monoclonal

H3

LMP-1

latent membrane protein LMP-1

HHV4_LMP-1; latent membrane protein LMP-1

Human

IgG1

Latent membrane protein 1

This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Virus

Epstein-Barr virus (EBV)

H3 was selected by its affinity for GST-LMP1 from a human phage display library after 4 rounds of panning.

-20°C,2°C to 8°C

12352203