Bio-Connect

anti-Lunatic Fringe antibody

ARG40136
Arigo Biolaboratories
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetLFNG
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-Lunatic Fringe antibody
  • Delivery Days Customer
    23
  • Applications
    Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID3955
  • Target name
    LFNG
  • Target description
    LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Target synonyms
    beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; SCDO3
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203