Anti-MAdCAM-1 [MECA-89]

Absolute Antibody

Anti-MAdCAM-1 [MECA-89]

9

The antibody is specific for mouse MAdCAM-1. The antibody recognizes the second immunoglobulin domain, interfering with L-selectin interactions of MAdCAM-1. The mucosal lymphocyte homing receptor MAdCAM-1 is expressed in the high endothelial venules of th

The antibody bound to the second domain of MAdCAM-1 and did not block MAdCAM-1-dependent binding in vitro (Streeter et al., 1988; PMID:3340147). The antibody was used for immunohistochemical analysis of healthy AKR control mice and it showed faint basal expression of MAdCAM-1 in the terminal ileum (Bachmann et al. 2006). The antibody blocked interactions with L-selectin in vivo (Bargatze et al., 1995; PMID: 7542550).

ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

MECA-89

Rat

IgG2a

This is a reformatted rat IgG2a Fc Silent™ antibody, based on the original rat IgG2a format, created for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203