anti-MDC1 antibody [P2B11]
ARG22275
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityMouse
TargetMdc1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-MDC1 antibody [P2B11]
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDP2B11
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID240087
- Target nameMdc1
- Target descriptionmediator of DNA damage checkpoint 1
- Target synonyms6820401C03; AA413496; mediation of DNA damage checkpoint 1; mediator of DNA damage checkpoint protein 1; mKIAA0170; NFBD; Nfbd1
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
- ReactivityMouse
- Storage Instruction-20°C
- UNSPSC12352203