anti-MeCP2 phospho (Ser421) antibody [2E2]
ARG10762
ApplicationsDot Blot, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman
TargetMECP2
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-MeCP2 phospho (Ser421) antibody [2E2]
- Delivery Days Customer23
- ApplicationsDot Blot, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2E2
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4204
- Target nameMECP2
- Target descriptionmethyl-CpG binding protein 2
- Target synonymsAUTSX3; meCp-2 protein; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
- HostMouse
- IsotypeIgG1
- Scientific DescriptionDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203