anti-MICA + MICB antibody [6D4] (PE)

Arigo Biolaboratories

anti-MICA + MICB antibody [6D4] (PE)

23

Flow Cytometry

Research Use Only

Monoclonal

6D4

0.1 mg/ml

RPE

MICA

MHC class I polypeptide-related sequence A

HLA class I antigen; major histocompatibility complex class I chain-related protein A; MHC class I chain-related protein A; MHC class I polypeptide-related sequence A; MHC class I related chain A; MHC class I related sequence A; MIC-A; PERB11.1; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A; truncated MICA

Mouse

IgG2a

MICA: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]MICB: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Human

2°C to 8°C

12352203