anti-mTOR (human), Rabbit Monoclonal (RM274)

RevMAb Biosciences

anti-mTOR (human), Rabbit Monoclonal (RM274)

5

This antibody reacts to human serine/threonine-protein kinase mTOR. This antibody may also react to mouse or rat mTOR, as predicted by immunogen homology.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM274

Liquid

MTOR

mechanistic target of rapamycin kinase

FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FRAP; FRAP1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR; SKS

Rabbit

IgG

Serine/threonine-protein kinase mTOR

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a key role in cell growth, cell proliferation, and protein synthesis. mTOR mediates phosphoinositide 3-kinase and Akt/PKB signaling, resulting in phosphorylation of 4EBP1, and initiation of mRNA translation. A second pathway involves regulation of ribosomal S6 kinase, which affects ribosome biogenesis and translation elongation. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. Mutations affecting the gene results in Smith-Kingsmore syndrome. - Recombinant Antibody. This antibody reacts to human serine/threonine-protein kinase mTOR. This antibody may also react to mouse or rat mTOR, as predicted by immunogen homology. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a key role in cell growth, cell proliferation, and protein synthesis. mTOR mediates phosphoinositide 3-kinase and Akt/PKB signaling, resulting in phosphorylation of 4EBP1, and initiation of mRNA translation. A second pathway involves regulation of ribosomal S6 kinase, which affects ribosome biogenesis and translation elongation. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. Mutations affecting the gene results in Smith-Kingsmore syndrome.

Human

-20°C,2°C to 8°C

12352203