Anti-MUC1 [PAM4]

Absolute Antibody

Anti-MUC1 [PAM4]

9

This antibody is specific for the PAM4 domain of the human MUC1 protein.

This antibody was used for immunohistochemistry on normal adult tissues and neoplastic tissues. This yielded no to weak staining in normal tissue and stronger staining in 85% of the neoplastic tissue (US7238786). ELISA was performed on blood serum of healthy humans, pancreatic cancer patients, pancreatitis patients, ovarian cancer patients and breast cancer patients (US7238786). This antibody was used to treat mice that were given the CaPanl tumor. The animals showed regression of tumor (US7238786). ELISA was performed on blood sera of cancer patients using this antibody (Gold et al, 2005; pmid:16344318). Immunohistochemistry was performed on 63 PanIN and 36 IPMN lesions using this antibody (Gold et al, 2007; pmid:18094420). Flow cytometry was performed on the cell lines: RPMI 8226, U266, MC/CAR JJN-3, KMS12-BM, KMS 12-PE, DUL4, MUC1, breast carcinoma cell lines, MCF7, MDA-MB468, T47D, ZR-75-30, and a pancreatic carcinoma cell line, CaPan-1. This was done using this antibody (Burton et al, 1999; pmid:10541345). A western blot was performed using this antibody (Burton et al, 1999; pmid:10541345).

Flow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

PAM4

MUC1

mucin 1, cell surface associated

ADMCKD; ADMCKD1; ADTKD2; breast carcinoma-associated antigen DF3; CA 15-3; cancer antigen 15-3; carcinoma-associated mucin; CD227; EMA; episialin; H23 antigen; H23AG; KL-6; krebs von den Lungen-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; mucin 1, transmembrane; mucin-1; peanut-reactive urinary mucin; PEM; PEMT; polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen

Human

IgG1

Mucin-1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203